Mesothelioma Explained in Full

Monday, July 12, 2010

Mesothelioma Explained in Full

Mesothelioma is a cancer associated with asbestos exposure. The asbestos fibers get lodged in membranes that surround vital organs of our bodies.

There are three kinds of Mesothelioma:

The most common form is called Pleural Mesothelioma which attacks the pleura or inner lining of the lungs. The asbestos fibers inhaled develop scars causing damage to the cells found in the inner lining. Symptoms tend to be a lack of breath, pains in the chest and retention of fluid in the lungs.

The second type is called Peritoneal Mesothelioma which damages the cells found in the inner lining of the stomach. Symptoms include pain in the abdomen, constipation and feelings of nausea. Cases of this nature are rare.

The third but very uncommon type is called Pericardial Mesothelioma which affects the lining surrounding the heart. The symptoms experienced by sufferers include pains in the chest, palpitations and a mild cough.

Although there is still no cure, there are treatments available to help ease pain and extend a patients lifespan. Surgery, chemotherapy and radiation have all been used to combat and reduce the spread of cancerous cells. Early diagnosis usually improves a patient's response to treatment.

The Butman system is a term used to describe different stages of a tumour caused by mesothelioma. The first stage signifies a presence in either the right or left side of the pleura, pericardium or diaphragm. The second stage is where the tumour has spread to both sides, the oesophagus, heart, chest wall or lymph nodes. The third stage is where the cancer has spread from the diaphragm into the peritoneum or abdominal cavity lining and is known as the serious assaulting phase. Stage four indicates the tumour has spread to the other organs through the bloodstream. CAT scans, MRI testing and X-rays are used to determine which stage a patient has reached. This information is vital in deciding the type of treatment that should be used.

Once the consequences of jobs using asbestos were recognised, thousands of people sued for damages. Certain companies were found guilty of concealing medical facts from their employees and were well aware of the potential hazards. As a result, the courts upheld the claims and bankrupted the majority of firms in this field, particularly mining and construction companies.

Any exposure to asbestos fibers can be deadly. Families of workers were also prone to asbestos related illnesses as these fibers were often carried home on clothing or hair. Washing the clothes was particularly dangerous.

There are more than 3,000 people diagnosed with mesothelioma every year in the U.S.A. This number is much larger worldwide. Asbestos is still being used in other countries, potentially exposing hundreds of thousand of people to a cruel death. We can only hope that they find a cure soon.

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Who Gets Mesothelioma - Your Genes Play a Part

Friday, July 2, 2010

Who Gets Mesothelioma - Your Genes Play a Part

Some mesothelioma researchers are proposing a genetic component to this aggressive cancer long associated with asbestos. At the Mesothelioma Applied Research Foundation's 2010 International Symposium, Jill Ohar MD of Wake Forest School of Medicine reported on research that supported the possibility that people who develop mesothelioma may have a genetic susceptibility.

Between 1940 and 1980, asbestos was an extremely common material in American industry, used in shipbuilding, aircraft fabrication, plumbing, insulation, railroad and automotive brakes and clutches, ceiling tile, floor tile, drywall, fireproofing materials, cement, and literally hundreds of other uses. An estimated 40 per cent of the US workforce, about 27 million Americans , was exposed in their workplaces to asbestos. The large majority of those exposed have not developed mesothelioma. The number of new mesothelioma cases identified each year has stayed constant at about 3000 per year.

The relatively small number who develop mesothelioma has led researchers to ask what might be the differences, among workers who experienced the same exposure to asbestos, between the majority who did not develop mesothelioma, and those who did.

Ohar and her colleagues worked from their database of 5000 people who had been exposed to asbestos, of whom 327 developed mesothelioma. They asked all of them about their asbestos exposure and their general health status. Their answers showed some very interesting patterns.

  • Age of first exposure: those workers who developed mesothelioma tended to be younger at their first exposure to asbestos. In the 1940's, they were the young men and women who volunteered out of high school, at age 17 or 18 to join the military, or work in defense industries. Cells in younger people tend to be more vulnerable to carcinogenic (cancer-causing) agents. Even a few years' delay, time spent in college or in work that did not involve exposure to asbestos, seems to have had a protective effect.
  • Military service: Mesothelioma patients were more likely to have served in the military. Service in the military increased the odds of exposure to asbestos.
  • Other cancer diagnoses: Mesothelioma patients were three times more likely than other workers exposed to asbestos to have had another cancer diagnosis at the time of diagnosis of their mesothelioma. This suggests a greater vulnerability, probably genetically mediated, to carcinogenic agents.
  • Cancer in first-order relatives: People diagnosed with mesothelioma were also three times more likely than other workers exposed to asbestos to have a first-order relative (a parent, a brother or a sister, or a child) who had a cancer diagnosis. Children of people with a mesothelioma diagnosis were seven times more likely to have a cancer diagnosis.
The message in Dr Ohar's research is that mesothelioma may be part of a broader genetic susceptibility to cancer-causing agents. Genetic susceptibility by itself does not lead to a diagnosis of meso. Exposure to asbestos does not guarantee that a person will get meso. But combine exposure, especially at a young age, with genetic susceptibility, and the odds for developing mesothelioma rise dangerously.

If you or a loved one has been exposed to asbestos fibers, especially in the workplace, and has received a diagnosis of mesothelioma, you need to consult with an experienced asbestos mesothelioma lawyer to determine whether you may have an actionable case against the employer.

READ MORE - Who Gets Mesothelioma - Your Genes Play a Part

 
 
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